XRD, FTIR, ICP-MS, TGA, and DSC confirmed presence of Ag and PO4 groups, whereas electron microscopy showed a decrease in Ca and an increase in Ag ions, decreasing Ca/P ratio with increasing surfactant concentrations. Preliminary biocompatibility and bactericidal capacity of the scaffolds were tested using human osteoprogenitor (hOP) cells and methicillin-sensitive S. The augmented scaffolds were evaluated utilizing X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and inductively coupled plasma mass spectroscopy (ICP-MS) to verify the presence of Ag and phosphate (PO4 ) groups followed by electron microscopy, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to gather information of chemical and physical properties. Scaffolds were 3D printed and augmented with Ag by external attack on the surface by silver nitrate (AgNO3 ) at varying concentrations (0.1, 1.0, 10% wt/wt of scaffold). Utilizing beta tricalcium phosphate (β-TCP) as bone grafting material augmented with silver (Ag), a custom graft may be 3D printed to overcome limitations and minimize potential infections. For critical sized defects, the common approach to reconstruction is a tissue transfer procedure but is subject to limitations (e.g., donor site morbidity, cost, operating time). Injuries requiring resection of tissue followed by autogenous bone transfer may be prone to infection by Staphylococcus aureus, impeding recovery and increasing medical costs. It was also proposed not to completely exclude the partial participation of silver chloride along with the silver proteinates in this process.
SILVER BLUE SKIN SKIN
A hypothetical mechanism based on a perspiration system for delivering the silver compounds from the gastrointestinal tract to the skin for argyria was proposed. Illustrative experiments included the observation of color change (visual and using UV-Vis spectrometry) under different light exposure conditions of silver chloride sol in a sweat-simulating solution, in vials and under pig skin (in direct contact). They are: (1) the process of delivering silver compound from the gastrointestinal tract to the skin and (2) the possibility for silver chloride to participate in this process along with the silver proteinates. The aim of the present work was to draw researchers’ attention to two aspects of the argyria that until now have not received enough consideration. Argyria is an acquired skin condition that appears after the exposure or consumption of silver, leading to blue or grey coloration of the skin and mucosa.
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